I always end up with lots of vacation photos. Two-page layouts are great when you have many pictures you want to scrap.
But sometimes you have a great photo (or two) that you really want to showcase. Solution? Blow it up!
I printed my left photo as an 8x10, centering it on the left side of my layout (at the top...), adding a block of paper, a border strip and title under the photo. The other half of my layout uses another block of paper to anchor the remaining 4x6 photos and journaling card.